USC ranks highly among U.S. medical schools for its basic science and clinical research. The Department of Medicine is one of the leading contributors to both basic science and clinical research at the Keck School of Medicine.
Many house officers participate in the active research efforts of our faculty. To foster and promote the development of those individuals anticipating academic careers, house officers may participate in research blocks in which they can perform faculty supervised research. Many of our residents have the opportunity to present their research at national conferences, such as ATS, Chest, DDW, AASLD, ASCO, and more.
division of gastroenterology research
Dr. Rosen is a prolific physician-scientist with more than 180 original peer-reviewed manuscripts investigating the cellular and molecular underpinnings of a wide spectrum of innate and adaptive immune responses and developing novel paradigms in liver diseases. His federally funded research program has provided significant insights into the roles of multicellular immunity in liver disease, particularly to the hepatitis C virus (HCV) and, more recently, in non-alcoholic fatty liver disease and potential therapies. Dr. Rosen’s laboratory has worked on HCV in the past 20 years, characterizing the diverse roles of multiple cell types (T cells, dendritic cells, macrophages, NK cells, liver sinusoidal endothelial cells and trophoblasts) in mediating protection/recovery, persistence and treatment-induced cure.
division of Pulmonary and critical care
Dr. Borok's clinical interests include acute lung injury and intensive care. Her research interests include transcriptional and epigenetic regulation of alveolar epithelial cell differentiation/plasticity, modulation of alveolar epithelial cell phenotype and recovery following lung injury, role of alveolar epithelium in pulmonary fibrosis, biology of lung stem cells and alveolar epithelial tight junction regulation. She’s currently spearheading a major research project on lung cell regeneration with the support of to a multi-year grant from the NIH. In her role as director of Hastings Center for Pulmonary Research, Dr. Borok has worked with the NIH on various pulmonary research for over 20 years.
division of oncology
An active researcher, Dr. Lenz’s laboratory focuses on topics including the regulation of gene expression involved in drug resistance, patients at high risk of developing colorectal cancer, and determination of carcinogenesis, methods of early detection, and better surveillance of these cancers. Dr. Lenz is the author of numerous peer-reviewed publications and invited papers, reviews, and editorials. In addition to his laboratory being NCI funded, Dr. Lenz has been the recipient of multiple awards.